Role of Melatonin with Lansoprazole in Treating Peptic Ulcer in Rats

Peptic ulcer is common in present days due to stress and anxiety. Peptic ulcer is thought to result from an imbalance between acid-pepsin secretion and mucosal defense factors. Though currently available drugs provide adequate relief from pain, promote healing, the problem of relapse has eluded success. The present study was designed to evaluate the combination effect of melatonin with lansoprazole against pylorus ligation induced ulcer model in rats. Albino Wistar rats of either sex were divided into 4 groups of 6 animals each. The antiulcer effect of the combination of melatonin 0.108 mg/200 g and lansoprazole 0.54 mg/200 g b.w orally was compared with the reference standard lansoprazole 0.54 mg/200 g b.w orally. The ulcer index and other biochemical parameters like volume, pH, free acidity and total acidity of gastric juice were estimated. The ulcer index and other biochemical parameters like volume (***P < 0.001), free acidity (***P < 0.001), total acidity (***P < 0.001) and pH (*P < 0.05), of gastric juice showed reduction when compared to control and standard lansoprazole. The percentage protection of combination was 90% as compared to standard lansoprazole 82.8%.Thus the combination of lansoprazole with melatonin was found to be synergistic in nature when compared to lansoprazole alone.